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Vitamin B12 does not have a tolerable upper intake level set by the Food and Nutrition Board, because the risk of toxicity from oral supplementation is low

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Myocardial remodelling characterized by fibrosis and hypertrophy, impaired microcirculation, abnormal protein function caused by advanced glycation end products, changes in myocardial metabolism and abnormal mitochondrial function have been noted as associated factors of diabetic cardiomyopathy [14]