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Los frmacos GLP-1, entre los que se incluyen liraglutida , semaglutida y tirzepatida , originalmente desarrollados para tratar la diabetes, cuentan con la aprobacin de muchos pases para el tratamiento de la obesidad

The temptation to increase the dose beyond 2.4mg exists, but clinical data beyond that dose point is limited for weight management specifically

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However, semaglutide treatment was associated with higher discontinuation rates compared to placebo

Results have not been independently verified and will vary from person to person

534 Similar to the neurotransmitter systems discussed previously, glutamatergic signaling is influenced by the gut microbiome