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"The signal was always in the prevention space rather than the treatment space," he added

They are used to: Improve glycemic management in people with diabetes Support weight loss in individuals with overweight or obesity Reduce cardiovascular risk in certain patient populations Most recently, to treat moderate to severe obstructive sleep apnea These medications are typically prescribed at FDA-approved doses and titrated gradually to manage gastrointestinal side effects like nausea, diarrhea, and upset stomach

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Elderly subjects show a 40% to 50% higher area under the drug concentration time curve (AUC) and a 30% higher half-life compared to younger subjects, and therefore dosage reduction is recommended

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