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Ex vivo analysis of mitochondria derived from rats subjected to ballistic injury revealed decreases in the enzymatic activity of pyruvate dehydrogenase and glutamate dehydrogenase, which reduce input from glucose and glucogenic AAs into the citric acid cycle (reduced CoA-SH and acetyl-CoA concentrations), at 24 h after injury [72, 75]

Signoretti, D

Consequently, this reduction of free GSH induces an increase of ROS (KE3) generated by natural cellular metabolic processes (cellular respiration) of the organisms

Such findings, if successful, will provide significant market applications, enabling regulatory approvals