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This oxidized iron then binds to transferrin (TF) in the plasma, forming holotransferrin, which is subsequently taken up by cells via TfR1-mediated endocytosis ( 3+ is subsequently reduced to Fe 2+ by the metalloreductase six-transmembrane epithelial antigen of the prostate 3 (STEAP3), followed by its transport into the cytosol via DMT1 to join the labile iron pool (LIP) or be stored in ferritin (Yan et al., 2021

(Well cover that in more detail below)

200 to 400mg daily

She also suggests speaking to a behavioral health provider beforehand to screen for issues that could exacerbate mental health problems while on the medication, such as eating disorders or unmanaged mental health concerns

PLoS ONE 7:e48934

These studies imply the need for iron sufficiency to maintain optimum thyroid function [45]