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Trial registration ClinicalTrials.gov identifier, NCT05227196

Compounded GLP-1 prescriptions are not FDA-approved and are not the same as brand-name medications

The body shifts into conservation mode that actually slows fat loss and accelerates muscle breakdown

GLP-1 produced naturally is rapidly broken down by the body

As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34

Henry Sobo, M.D