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Response: As stated in the CY 2026 PFS proposed rule (90 FR 32675), for performance year 2025 and subsequent performance years, the revised definition we proposed in (1)(ii)(B) of the definition of a beneficiary eligible for Medicare CQMs would align with our modifications to the stepwise assignment methodology and approach to identifying the beneficiaries assignable to an ACO, as finalized in the CY 2024 PFS final rule (88 FR 79162) and described at 425.402(a)(5), where physician assistants, nurse practitioners, and clinical nurse specialists were added to the process for identifying beneficiaries assignable to an ACO beginning in performance year 2025

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This reciprocal communication integrates metabolic reprogramming with immune regulation, positioning ferroptosis as a key determinant of macrophage-driven tumor biology