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Together, these pathways represent complementary approaches to metabolic regulation, making dual agonists like tirzepatide valuable tools for studying integrated metabolic control

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Dosage adjustments should be made in 2.5-mg increments after at least 4 weeks at the current dose, with a maximum dose of 15 mg weekly

Safe discontinuation of tirzepatide requires medical oversight and individualized planning, even though formal tapering is not pharmacologically necessary