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Subsequently, dissections were performed under the same conditions as above

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Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion

Several studies have also provided evidence that mitochondrial function is impaired in diabetes and thus the additional insult of metformin-induced dysfunction would be detrimental to patients with T2DM (145, 146), as was seen with the effects of metformin on old (AD10) C

This decline correlates strongly with increased visceral fat accumulation