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Targeting the folate pathway by knocking down related genes, such as aldehyde dehydrogenase 1 family member L2 (ALDH1L2) or methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), or using methotrexate significantly inhibited distant metastasis [32]
doi: 10.1016/S1474-4422(10)70223-4 19 NorthamEAAndersonPJJacobsRHughesMWarneGLWertherGA
Food Chem Toxicol 50(2):390398
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This gap leaves open the possibility of unintended psychiatric effects, not because the drugs are inherently harmful, but because their impacts haven't been properly studied among users with mental health conditions
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