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In the SURMOUNT-4 trial, participants who stopped Mounjaro after 36 weeks regained around 14% of their body weight over the following year, but still kept around 10% weight loss compared to baseline

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Furthermore, DSIP influences the hypothalamic-pituitary-adrenal (HPA) axis, regulating the bodys response to psychological and physical stress and significantly lowering cortisol (the primary stress hormone)

Inside that overarching trial, Lilly nested two "basket" sub-studies to test whether the weight loss would carry specific obesity comorbidities with it: Knee osteoarthritis basket: 574 participants with symptomatic knee OA Obstructive sleep apnea basket: 243 participants with moderate-to-severe OSA The design matters

Theyre basically making wellness a right, not a privilege

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