The endocrinologist I have spoken with regularly about this has mentioned that semaglutide is more muscle sparing than Mounjaro, which raises interesting points about how wide this market may be in terms of each modality perhaps retaining a market share for a very specific type of body composition requirement
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Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity
To be doubly sure that unplanned pregnancy doesnt happen, it may be wise for women who are on Ozempic and similar drugs to use condoms and of course an IUD would also be a very safe option.
Preclinical data also indicate potential anticancer effects independent of weight loss, such as modulation of tumor cell metabolism and inflammation, as well as reprogramming of tumor-associated macrophages toward anti-tumor (M1-like) phenotypes and enhanced cytotoxic T-cell infiltration in animal models
However, GLP-1 receptor occupancy and downstream signaling may persist even as plasma levels drop, creating a lag between apparent drug 'wear-off' and loss of appetite suppression or glucose control
