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However, treatment discontinuation due to adverse events occurred in 24.6% and 3.9% of participants, respectively, mainly due to gastrointestinal adverse events

Clot Formation : The activated platelet plug serves as a scaffold for the deposition of fibrin, a protein that forms a mesh-like network to stabilize the clot further

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They also reduce the amount of sugar your liver releases

Other long-term considerations include gastrointestinal adaptation (most patients find side effects diminish significantly after the first 3-6 months), nutritional deficiencies that can develop with prolonged reduced caloric intake, and the psychological adjustment of maintaining a dramatically different body weight and relationship with food