Women with active IIH were identified and recruited from a single tertiary referral hospital (Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, United Kingdom)
NPM1 mutations are known to result in aberrant cytoplasmic localization and downregulation of the NPM1 protein 28 , as observed in our data (log 2 fold change (FC): 0.44, P 0.2 for C3, C7 and C8)
If the sample contains insoluble matter, centrifuge or filter (0.22 m or 0.45 m filter) before use
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Travel-specific insulin coolers or medical transport containers with gel packs can maintain refrigeration temperature for 2448 hours without electricity, but you must pre-condition the gel packs and verify internal temperature with a probe thermometer before placing the vial inside
The downside of its hybrid nature is that - similar to the inorganic sunscreens zinc and titanium dioxide - Tinosorb M also leaves a white cast on the skin that can be bothersome on darker skin tones
