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doi: 10.1007/s12035-015-9584-5 108 Sanchez-LemusEMurakamiYLarrayoz-RoldanIMMoughamianAJPavelJNishiokuTet al
Furthermore, high levels of copper in acidic and or hypoxic environments accelerate A 142 aggregation via primary nucleation and aggregation of other proteins, respectively (Sasanian et al., 2020
Although the precise mechanisms underlying KDs effects in PD remain incompletely understood, evidence suggests that the diet can modulate glucose utilization in the brain, neurotransmitter metabolism, insulin signaling, oxidative stress, neuroinflammation, and ion channel activity, particularly potassium channels [20]
It has been proposed that deficiency of intracellular cysteine induces ferroptosis primarily due to failure to synthesize GSH, which protects cells against ROS and lipid peroxidation 18
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