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mTOR coordinates protein synthesis, mitochondrial activity and proliferation

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18 The SYNERGY-NASH (A Study of Tirzepatide [LY3298176] in Participants With Nonalcoholic Steatohepatitis) trial, 19 a phase 2b dose-finding study, randomized 190 patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis to receive weekly injections of the GLP-1 and GIP dual agonist tirzepatide 5 mg, 10 mg, or 15 mg or placebo for 52 weeks

Ben: It's easy to be disillusioned with why would I go after something large population if there's already something else that treats a large population good enough

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The deceleration curve Weight loss during months seven through twelve follows a predictable deceleration pattern