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Circulation 136:15481559 Pessoa TD, Campos LC, Carraro-Lacroix L, Girardi AC, Malnic G (2014) Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule

Zepbound is unique, however, because it is a combination GLP-1 with a glucose-dependent insulinotropic peptide (GIP)

The GLP-1 receptor is found on immune cells in the gut, and some preclinical studies indicate that GLP-1 activation may actually reduce pro-inflammatory signaling

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