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Enzymatic defects in pyruvate kinase that have been characterized include thermal lability, increased K m for PEP, and decreased activation by Fru-1,6-BP

Fevers help boost immune responses, including interferon, a key antiviral molecule

Contact your GP or diabetes specialist promptly if you experience severe persistent vomiting or diarrhoea, severe abdominal pain (particularly radiating to the back), signs of hypoglycaemia, symptoms of gallbladder problems, vision changes, or unexplained persistent nausea beyond the first few weeks

Running 8-week cycles with 4-week breaks means approximately 8 months of active use per year rather than 12

Incorrect technique: shaking the vial like a salad dressing