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doi:10.1016/j.tjnut.2025.06.026 Akhi R, Lavrinienko A, Hakula M, et al

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In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]