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"Pharmacist Rounds: Surgical Irrigation Fluids--To Warm or Not-Although the jury is still out, the majority of published reports support the use of warm irrigation fluids to minimize the risk of hypothermia in surgical procedures." Pharmacy Times 75.8 (2009): 56

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Theres growing evidence that alternative sites of activity, like the gut microbiome, tissue-resident immune cells, and the gastrointestinal system, may potentially be significant in metformin efficacy (Thakkar et al., 2013