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Furthermore, AKT may directly activate the nicotinamide adenine nucleotide kinase (NADK) responsible for the phosphorylation of NADH forming NADPH (Jeon et al., 2012

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This mechanism might rely on interleukin-1 receptorassociated kinase 1, which is one of the key Toll-like receptor (TLR) 4 intracellular signaling kinases (Maitra et al., 2009)

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