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Treatment for Insomnia Even though many women and men rely on over-the-counter melatonin supplements to help them sleep, hormone replacement therapy, such as estrogen replacement therapy, is a more effective treatment for insomnia related to a hormonal imbalance

EXPERIMENTAL Animals The experiments were conducted using 60 male APPswe/PS1dE9/Blg (APP/PS1) mice with a mixed C57Bl6/Chg genetic background and 20 male C57Bl6/Chg (wild-type, WT) mice