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Inflammasomes, particularly the NLRP3 inflammasome, play a central role in regulating this phase by sensing both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) released during injury, such as those generated in thermal burns

Genetic testing is used to see if a person has a genetic variant that causes cEDS

doi: 10.1371/journal.pone.0011302 138 ChappelS

The kidney is a highly metabolic organ, rich in oxidation reactions in mitochondria, which makes it vulnerable to damage caused by OS, and several studies have shown that OS can accelerate kidney disease progression

After absorption in the gut, dietary vitamin B6 is converted in the liver to its biologically active forms, pyridoxal 5-phosphate and pyridoxamine-5-phosphate, which are coenzymes in homocysteine metabolism.5 The endogenous conversion of dietary vitamin B6 to its active forms is regulated by the enzyme pyridoxamine-5-phosphate oxidase

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