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The medication's effects are generally dose-dependent, though the optimal dose should be determined based on both efficacy and tolerability

As depicted in Figure S8, the scavenging capability of PDA against OH displays concentration-dependent behavior

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[DOI] [PubMed] [Google Scholar] 82.Li Q., Lancaster J.R., Jr

The operational calculus is becoming straightforward: hybrid models reduce screen-failure rates by extending geographic reach while preserving investigator oversight over critical procedures, delivering a patient enrollment advantage that translates directly into shortened study timelines and reduced per-patient cost