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Although metformin increased GLP-1R level, exendin (939) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function

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Zepbound administration starts at 2.5 mg for the first 4 weeks, then increases to 5 mg