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While free NAPQI is the direct cause of toxicity, it cannot be detected or quantified in its free form in plasma or assay buffers due to its immediate reactivity with thiols and proteins

These changes have run in parallel with the increasing prevalence of genotypes 1a, 3 and 4, associated with male gender and with IDU, which has become the most frequent route of infection

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All 50 patients 100% lost weight, with an average weight loss of 15.5% body weight or 43 pounds over the year

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