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24,25 Leptin responsive neurons in the ARC include those containing the agouti-related peptide (AgRP) and orexigenic peptides neuropeptide Y (NPY), and those containing the anorexigenic peptides -melanocyte-stimulating hormone (-MSH) and cocaine and amphetamine-regulated transcript (CART)

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This offers them the proper tools and know-how to deeply penetrate the dermis for concentrated deposition of high-quality ink, which lasts longer and looks better