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In patients with T2DM, the pancreas responds initially by expanding the mass of -cells and increasing insulin secretion to compensate for the increased metabolic demand [1]

Antioxid and Redox Signaling (2019) 30(8):112443

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As expected, administration of BSO in the established high ACTL6A-expressing PDX tumors (cases 1 and 3) attenuated tumor progression