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1 Introduction In the 1930s, Nobel Prize-winning chemist Vincent du Vigneaud isolated homocysteine (Hcy) from bladder stones

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Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis