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Moreover, OPi, a novel OXPHOS complex I inhibitor, showed antitumor activity in MAPKi-resistant BRAF-mutant melanoma by promoting glycolytic metabolism and suppressing the TCA cycle through the LKB1-AMPK axis [55]

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Unlike MT-1 whose linear backbone and tridecapeptide length confer preferential MC1R activity, MT-IIs cyclic heptapeptide structure produces a more compact, conformationally rigid pharmacophore with enhanced affinity at the centrally expressed MC3R and MC4R subtypes alongside maintained MC1R activity and generating the distinctive multi-system pharmacological profile that encompasses skin pigmentation through MC1R, pro-sexual and pro-erectile effects through hypothalamic and limbic MC3R/MC4R activation, and anorexia and energy balance modulation through hypothalamic MC3R/MC4R

Notably, HSPA1A has been reported to interact with key regulators of ER stress and mitochondrial function, suggesting that its downregulation may broadly affect cellular stress resilience

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By week 12, the mean blood pressure decreased from baseline in the LY group compared to the placebo group