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Future Directions: Research is expanding beyond weight loss to evaluate CagriSema's effects on cardiometabolic complications (cardiovascular disease, NASH, sleep apnea, HFpEF), special populations (adolescents, diverse ethnic groups), and quality of life outcomes

(4) Effros RB

It does not have the same level of clinical evidence as approved medications for inflammatory bowel disease, autoimmune disease, or other diagnosed inflammatory conditions

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However, this potency advantage comes with the trade-off of more rapid tachyphylaxis and greater cortisol elevation