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Multiple randomized controlled trials show that adding semaglutide to existing metformin therapy produces 15-25% greater weight loss than either medication alone
GLP-1 medications are designed for long-term use, particularly for managing chronic conditions such as obesity and type 2 diabetes
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Nine in 10 of those obtaining weight-loss medication do so privately, with heavy restrictions to access via the NHS Novo Nordisk last week said prescriptions for the pills have surpassed three million since launching in early January in the United States
For instance, GLP-1 receptor activation influences brain regions associated with appetite and reward, leading to reduced food intake
