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TRIUMPH-4 showed 26.4% weight loss at 9mg still substantially above any currently approved medication

Adverse Effects * Headache * Nausea * Abdominal pain * Diarrhea or constipation * Flatulence Long-term use * Vitamin B12 deficiency * Hypomagnesemia * Increased fracture risk * Increased risk of enteric infections (e.g., Clostridioides difficile) * Possible increased risk of community-acquired pneumonia Contraindications * Hypersensitivity to omeprazole or other PPIs * Use with drugs where interaction is contraindicated (e.g., certain formulations of rilpivirine) Drug Interactions * May reduce activation of Clopidogrel (clinical significance varies

between-group difference, 1.16

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic beta-cells