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doi: 10.1371/journal.pone.0088136 233 OlbrichK

In one of these studies, measuring brain GSH levels with in vivo proton MRS yielded a correlation in GSH reduction and decline in cognitive functions with 87.5% sensitivity and 100% specificity (Ribas et al., 2014)

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Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses

It is reported that overexpression of NRK1 in NIH3T3 cells and hepatocytes elevates cellular NAD + levels in response to NR addition

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