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Simponi has been licensed for use in the UK in adults (over 18) who have moderate to severe ulcerative colitis and have not responded to other medications

UK guidance (MHRA and NICE) advises checking B12 levels in patients on metformin who develop symptoms of deficiency (anaemia, neuropathy) and considering periodic monitoring in those on long-term therapy

This is important during chemotherapy, when nerve damage can happen

TB-500 may have a stimulatory action on myoblasts and myocytes

The dosage is then increased gradually to achieve the desired weight loss and appetite suppression