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Indeed, 17-AAG (Tanespimycin) and 17-DMAG (Alvespimycin), two synthetic derivates of Geldanamycin antibiotic, used as HSP90 inhibitors, improve physiological parameters in bleomycin-induced pulmonary fibrosis mice model 25,26

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This may be the improvement or aggravation that tested agents can exhibit of healing

In an open uncontrolled trial, 32 IC/BPS patients were treated with 400 mg micronized PEA plus 40 mg polydatin (a naturally occurring precursor to the polyphenol resveratrol) twice daily for three months followed by once daily for three months

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