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Specifically, the indirect mechanism is chelation of transition metals, which prevents participation within the Haber-Weiss (Kehrer, 2000) or Fenton reaction, while the direct mechanism involves donating or receiving of electrons, scavenging radicals, and consequently preventing their reaction with biological molecules
This makes it a gentler alternative to harsher brightening ingredients that might cause irritation
Enhancement of SAMe levels permit it to act as the cofactor of COMT, which prevents catalysis in the first step in a degradation pathway of the catecholamine neurotransmitters, and can therapeutically decrease COMT enzyme activity [183]
doi: 10.1093/ajcn/81.1.277S
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Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S
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