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In addition, GLP-1RAs exert pleiotropic effects by promoting weight loss, activating GLP-1 receptors on neurons and T cells, and targeting receptors in multiple organs

Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]

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Li et al., 2019a