While the mechanisms differ from tirzepatide, the clinical outcomes are comparable for most patients with type 2 diabetes
Last reviewed: May 28, 2026 Last updated: May 28, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Most of the survey respondents (90%) had been prescribed GLP-1 medication for weight loss, while 24% said that the medication was prescribed to treat PCOS (respondents were allowed to select more than one answer here)
While semaglutide helps to reduce hunger levels, what you put into your body and the energy you exert is ultimately the cause of your weight loss
Semaglutide injection (Wegovy ) is a glucagon-like peptide-1 (GLP-1) receptor agonist that is given as a once-weekly subcutaneous injection for chronic weight management in specified subgroups of patients (see FDA indications below)
Additionally, GLP-1R signaling in -cells activates mTOR-dependent transcription of hypoxia-inducible factor 1 alpha (HIF-1), which upregulates glucose expression and promotes glucose metabolism [8, 9]
