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Polymeric immunoglobulin receptor (pIgR), a component of secretory IgM which mediates the IgM transcytosis through the mucosal epithelial cells, also occupies the cleft in the IgM pentamer when bound, and therefore pIgR and AIM cannot bind IgM at the same time (Supplementary Fig

(2020) N-Acetylcysteine as an adjunctive treatment for bipolar depression: a systematic review and meta-analysis of randomized controlled trials

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They look across multiple unconnected sources (unconnected is important, so youre not just stuck in an echo chamber) and see how many voices might be saying the same thing