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J Exp Med

A study has shown that lixisenatide inhibits inflammation of RA in human FLSs by downregulating IL-6, IL-8 and TNF-, while also inhibiting cellular communication pathways including c-Jun N-terminal kinase (JNK) and NF-B [239]

The dosing frequency for sublingual drops is typically once daily

Finally, some research suggests that GLP-1 may also influence processes in the brain in a way that limits cravings and overeating

However, previous large-scale trials comparing intensive versus standard glycemic control, such as ACCORD and ADVANCE, demonstrated that while intensive glucose lowering modestly reduced the incidence of nonfatal MI, it did not significantly reduce CV mortality among patients with T2D (70, 72, 73)

Tail vein samples were obtained for immediate glucose measurement as above, or into lithium heparin-coated microvette tubes for plasma insulin measurement using a mouse insulin-specific HTRF (Cisbio)