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The STEP trial program demonstrated that semaglutide doses from 1.0 mg to 2.4 mg weekly produce dose-dependent weight loss, with participants achieving 1015% body weight reduction over 68 weeks

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Barden CJ, Wu F, Fernandez-Murray JP, Lu E, Sun S, Taylor MM, Rushton AL, Williams J, Tavasoli M, Meek A, Reddy AS, Doyle LM, Sagamanova I, Sivamuthuraman K, Boudreau RTM, Byers DM, Weaver DF, McMaster CR