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As illustrated in Figure 1, characteristic alterations in the erythrocyte membrane, such as blebbing, cellular shrinkage, and externalization of phosphatidylserine (PS), are observed during eryptosis, mirroring features typical of apoptotic cell death ( FIGURE 1 A key mediator of eryptosis is the rise in cytosolic Ca 2+ , which can be induced by osmotic shock, oxidative stress, or other stimuli (Qadri et al., 2012)

1 The peptide is not found freely circulating in human plasma

Iruzubieta P, Arias-Loste MT, Fortea JI, Cuadrado A, Rivas-Rivas C, Rodriguez-Duque JC, et al

Psychiatry 21 , 320327 (2015)

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it is not approved here, its evidence is modest and graded weak, and it carries a real harm signal at higher doses