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This is what makes them convenient for patients, one injection per week is much more manageable than daily injections, but it also creates the timing questions that do not arise with shorter-acting peptides

Additional studies are needed to determine whether SGLT2 inhibitors can meaningfully delay kidney disease progression in people with non-albuminuric or non-proteinuric DKD

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[1] Patients considering any modification to standard dosing regimens should discuss this thoroughly with their GP or endocrinologist, as unsupervised dose adjustments may compromise treatment effectiveness and safety

On the basis of these studies, food intake impacts the pharmacokinetics of semaglutide and it is necessary to advise patients to fast before administration of the drug [28]

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