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NICE recommends these early in treatment for many people with established cardiovascular disease or chronic kidney disease [3] Pioglitazone : An insulin sensitiser, though less commonly used due to side effects including weight gain and fluid retention DPP-4 inhibitors : These enhance incretin activity with a lower side effect burden than GLP-1 agonists but less weight loss benefit Tirzepatide : A newer dual GIP/GLP-1 receptor agonist available for type 2 diabetes (subject to local formulary approval) [3] For patients who cannot tolerate or do not respond adequately to Ozempic, other GLP-1 receptor agonists such as dulaglutide (Trulicity) or liraglutide (Victoza) may be considered
An overdose of semaglutide can cause severe nausea, vomiting, dizziness, and hypoglycemia (low blood sugar)
Comparing Your Options Step 3: Prepare for Your Appointment Thorough preparation increases your chances of a productive consultation and successful prescription
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The company didn't address the arthritis risk finding specifically, but said it welcomes independent research investigating the safety, efficacy and clinical utility of its products
Taking doses beyond this range increases risk of side effects like severe nausea, vomiting, and acute kidney injury without strong evidence of additional benefit
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