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As Mounjaro and Zepbound, Tirzepatide has been administered to millions of patients, generating a robust post-market pharmacovigilance dataset unavailable for Retatrutide

These findings indicate that studies using routine clinical practice data should present analyses for a range of grace periods, and provide drug utilisation estimates that account for both treatment discontinuation and reinitiation and are less sensitive to the technical definition of treatment discontinuation [31], rather than focusing on one arbitrary definition of treatment discontinuation

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