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In addition, lithium increases CaMKK2 expression in the striatum, an area of the brain that displays structural abnormalities in bipolar disorder [173, 174]
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A.GearingM.MiaoJ.et al (2019b)
Specific Issues Semaglutide : Possibly has a slightly increased rate of gastrointestinal discomfort Tirzepatide : As it is newer, long-term data are still in the process of emerging, but initial studies report a tolerable side effect profile Serious Risks (Rare) Pancreatitis Gallbladder disease Risk of thyroid C-cell tumors (observed in rodent studies) Note: These drugs should not be administered in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2)
