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This hypoxic environment in turn stabilizes HIF-1 in both cancer and stromal cells (114)

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these observations were accompanied by high levels of total phenols and the lignin precursors (hydroxyphenyl and syringyl), thus promoting the activities of POD and PPO [58, 59]

In cases of inoperability, radiotherapy, imiquimod, 5-flourouracil, photodynamic and target treatment for the hedgehog pathway can be other options for treatment (37)