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calcification of the pineal gland starting early in life and an impairment in the noradrenergic innervation to the gland or light detection capacity (ocular mydriases, cataracts) (2, 37)

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KRAS G12D is highly prevalent in pancreatic cancer, colorectal cancer and non-small cell lung cancer, yet it has long remained one of the most challenging KRAS mutations to target directly