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The process for the synthesis of semaglutide as claimed in claim 1, wherein in said step (4), the method for removing Alloc is Pd 0 (Ph 3 P) 4 And Me 2 NHBH 3 Combination of (2) or Pd 0 (Ph 3 P) 4 And PhSiH 3 In which Pd is removed 0 (Ph 3 P) 4 The dosage of the Alloc protective group is 0.1 to 0.5 time of the molar weight of the Alloc protective group

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Modulation of Microbiota-Gut-Brain axis by berberine resulting in improved metabolic status in High-Fat Diet-Fed rats